Abstract: The large-scale soil-rock mixture landslide is a kind of landslide type influenced by many factors such as engineering geological conditions, precipitation and earthquake, it is of great significance to study the causes of landslides and control methods for disaster prevention and mitigation, and for safeguarding the safety of people's lives and property. Based on Jiangdingya Landslide in Zhouqu, the causes and stability of the landslide are analyzed in details by means of historical data investigation, field geological investigation and numerical simulation, the corresponding comprehensive treatment measures are put forward as well. The results show that the topography, loose soil-rock are the internal factors that cause the landslide, while the continuous rainfall and the river erosion on the front edge of the landslide are the external factors that decrease the landslide stability. Based on the analysis of the landslide causes, the deformation of the landslide is effectively controlled by improving the structure of anti-slide pile wall, taking the lead in the application of prefabricated frame support, combined with the slope crack treatment project and other comprehensive treatment measures.The comprehensive treatment measures of the landslide can provide reference for similar high slope engineering and large-scale soil-rock mixture landslide treatment.