Abstract: The combined structure of prestressed anchor cable frames and stabilizing piles is an effective measure for reinforcing high accumulation slopes. To thoroughly reveal the mechanical behavior of such combined structures in reinforcing high accumulation slopes, a series of static model tests with a geometric similarity ratio of 1∶20 were carried out based on a practical high slope about 60 m in height. The slope surface displacements and mechanical characteristics of anchor cables, frame beams and stabilizing piles under step-by-step loading at the slope top were measured. The results show that the slope surface horizonal displacement increases nonlinearly with load and can be divided into three stages: linear-elastic small deformation, elastoplastic deformation, and large plastic deformation. The deformation zone is mainly located in the middle and upper parts of the slope. The upper prestressed anchor cable frames act as the main reinforcing component. The bending moment of the transverse beams shows a one-way distribution, while that of the longitudinal beams shows a two-way “M-shaped” distribution; the maximum bending moment of the transverse beam is about 0.3～0.4 times that of the longitudinal beam. The maximum bending moment of the stabilizing pile occurs at approximately 0.4 times the pile height above the pile base. Numerical simulation based on the model test shows that the slope stability factors before and after reinforcement are 1.11 and 1.33, respectively, and the failure mode changes from overall deep-seated sliding to local sliding in the middle and upper parts. Theoretical analysis of frame beams and stabilizing piles based on the elastic foundation beam model shows that the maximum bending moment errors of longitudinal beams, transverse beams and stabilizing piles between theoretical analysis, numerical simulation and model test are 3% and 7%, 18% and 8%, and 8.5% and 6.2%, respectively, indicating mutual verification among the three methods. The research reveal the reinforcement mechanism of multi-stage prestressed anchor cable frames combined with a single row of stabilizing piles, which can provide scientific guidance and reference for the engineering design of high accumulation slope reinforcement.