Abstract: With the intensification of human engineering activities, the incidence of karst ground collapse in Huadu district, Guangzhou has been increased annually. Therefore, it is crucial to conduct a risk zoning assessment of karst ground collapse. Based on the identification and analysis of contributing factors, nine key indicators were selected: degree of karst development, inflow rate of karst water from a single well, karst groundwater level and its fluctuations, karst water level drop, lithological structure and thickness of overlying soil layers, ground geomorphological characteristics, building density, and known collapse locations. A comprehensive risk assessment model of karst ground collapse in Huadu district was developed. Using matrix units within Huadu district as assessment units, the risk zones were divided into three levels: high, medium, and low risk area. The results show that high-risk zones account for 44.2% of the karst-developed areas, mainly overlapping with known collapse zones. Medium-risk zones constitute 5.5%, primarily in the southern and northwestern parts of the study area, characterized by Quaternary covered karst. Low-risk zones represent 50.3%, mostly located in the northern covered karst regions. These findings offer valuable reference for geological disaster prevention and mitigation in urban development planning.